Macbeth Act 4 Questions

4.1
1. How many witches appear in this scene?
3 witches. 
2. What messages does Macbeth get from the witches and their apparitions? Does he feel safe after the first three apparitions? Should he? How does he feel after the fourth, the line of kings?
The first apparition says to be wary of Macduff and careful of him. The second tells Macbeth he should be strong willed ruler-bold and brace and in other words he should not accept defeat. The third warns attacking armies coming, and tells Macbeth he won't be defeated until the kingdom of Norway attacks. 
3. What does Macbeth learn from Lennox at line 158? What does he plan to do about it?
That Macduff is running away to England, and in response Macbeth decides to send someone to try to kill as many of his family members as he can. 
4.2
1. What is Lady Macduff's reaction to her husband's departure for England (4.2.1-30).
Betrayed and angry
2. What is the function of the scene between Lady Macduff and her son (4.2.30-64)?
To have false impressions about his dad. 
3. What happens to Lady Macduff and her son?
They are killed by Macbeth 
4.3
1. What do we know at the beginning of the scene that Macduff doesn't know?
Macduff's family has been killed. 
2. What is the main issue between Malcolm and Macduff in the first part of the scene (4.3.1-32)?
Why might Malcolm be suspicious of Macduff? How does Macduff respond (4.3.32-38)? What changes when Macduff starts to leave at line 35?
That Malcolm doesn't want to go home because he's afraid of judgement since he ran away in the first place. 
3. What does Malcolm say about himself, and how does Macduff respond (lines 38-115)? What bothers Macduff more in a king, lust or avarice? Why does this character of Malcolm's surprise Macduff (lines 106-112)? (Malcolm's mother was the daughter of the Old Siward mentioned in line 135, which might explain why he is helping. The description of his mother sounds more like St. Margaret of Scotland, who in fact was later this Malcolm's wife.)
Ross tells Macduff his family is dead.